Tag Archives: RNA

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3-D RNA modeling opens scientific doors

3-D RNA modeling opens scientific doors - A team from the University of North Carolina at Chapel Hill have demonstrated a simple, cost-effective technique for three-dimensional RNA structure prediction that will help scientists understand the structures, and ultimately the functions, of the RNA molecules that dictate almost every aspect of human cell behavior. Reference: N. Dokholyan et al, Nature Methods, April 15 2012

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A surprising new kind of proton transfer

A surprising new kind of proton transfer - Common wisdom has it that protons only travel between molecules via hydrogen bonds: no hydrogen bonds, no proton transfer. Scientists at Lawrence Berkeley National Laboratory's Advanced Light Source and their colleagues at the University of Southern California investigating molecular components of RNA were surprised to find that protons can find ways to transfer even when hydrogen bonds are blocked. The discovery may open new opportunities for research in biology, environmental science, and green chemistry. Reference: "Ionization of dimethyluracil dimers leads to facile proton transfer in the absence of H-bonds," A. Golan et al, appears in 'Nature Chemistry' advance online publication at http://www.nature.com/nchem/index.html.

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Sponge-like spheres give RNA the armour it needs

  • Sponge-like spheres give RNA the armour it needs - MIT researchers have now come up with a novel delivery vehicle in which RNA is packed into microspheres so dense that they withstand degradation until they reach their destinations. The new system, described Feb. 26 in the journal Nature Materials, knocks down expression of specific genes as effectively as existing delivery methods, but with a much smaller dose of particles.