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Scientists uncover how ‘checkpoint’ proteins bind chromosomes - The development of more effective cancer drugs could be a step nearer thanks to the discovery, by scientists at Warwick Medical School UK, of how an inbuilt ‘security check’ operates to guarantee cells divide with the correct number of chromosomes. Reference: 'Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint,' J B A Millar et al, Current Biology, 19 April 2012 DOI: 10.1016/j.cub.2012.03.051