New proteins to clear the airways in cystic fibrosis and COPD

New proteins to clear the airways in cystic fibrosis and COPD – Scientists discovered a new strategy to help CF and COPD patients clear the thick and sticky mucus clogging their lungs, leading to life-threatening infections. The report online in the FASEB Journal shows the "SPLUNC1" protein and its derivative peptides may help thin mucus by affecting the epithelial sodium channel. Along with its implications for cystic fibrosis and COPD, the research enhances the understanding of hypertension due to its role in controlling blood pressure. Reference: 'Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways,' FASEB J, doi:10.1096/fj.12-207431 ; http://www.fasebj.org/content/early/2012/07/13/fj.12-207431.abstract

New proteins to clear the airways in cystic fibrosis and COPD – Scientists discovered a new strategy to help CF and COPD patients clear the thick and sticky mucus clogging their lungs, leading to life-threatening infections. The report online in the FASEB Journal shows the "SPLUNC1" protein and its derivative peptides may help thin mucus by affecting the epithelial sodium channel. Along with its implications for cystic fibrosis and COPD, the research enhances the understanding of hypertension due to its role in controlling blood pressure. Reference: 'Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways,' FASEB J, doi:10.1096/fj.12-207431 ; http://www.fasebj.org/content/early/2012/07/13/fj.12-207431.abstract

Author: Robert Slinn

Robert Slinn is ChemSpy's guest columnist. You can read his chemical news updates under the banner "Slinn Pickings". Robert is a Chartered Chemist (CChem), Member of the Royal Society of Chemistry (MRSC) and is a Visiting Researcher in the Department of Chemistry at the University of Liverpool. He has extensive experience in R&D: synthesis, analysis and analytical methods development; troubleshooting, consultancy, and teaching/training methods in industry and in academia. Robert is also 'Physical Methods' author for the Specialist Periodical Report series 'Organophosphorus Chemistry', published by Royal Society of Chemistry, Cambridge, UK. Robert has worked alongside David on the Bedside Book of Chemistry and a major Thomson-Reuters report on the state of the pharmaceutical industry for the 2011 International Year of Chemistry