Hydrogels can release drugs one at a time

Hydrogels can release drugs one at a time – A hydrogel that can be programmed to release different protein drugs one after the other rather than all at once could simplify the delivery of complex therapeutic regimens for various diseases. Researchers have used aptamers to functionalise a hydrogel made from natural polysaccharides to this end. Sequences of DNA that complement the aptamers then allow the proteins to be released at different stages.[cite]10.1021/ja305238a[/cite]

Hydrogels can release drugs one at a time – A hydrogel that can be programmed to release different protein drugs one after the other rather than all at once could simplify the delivery of complex therapeutic regimens for various diseases. Researchers have used aptamers to functionalise a hydrogel made from natural polysaccharides to this end. Sequences of DNA that complement the aptamers then allow the proteins to be released at different stages.(10.1021/ja305238a)

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Author: Robert Slinn

Robert Slinn is ChemSpy's guest columnist. You can read his chemical news updates under the banner "Slinn Pickings". Robert is a Chartered Chemist (CChem), Member of the Royal Society of Chemistry (MRSC) and is a Visiting Researcher in the Department of Chemistry at the University of Liverpool. He has extensive experience in R&D: synthesis, analysis and analytical methods development; troubleshooting, consultancy, and teaching/training methods in industry and in academia. Robert is also 'Physical Methods' author for the Specialist Periodical Report series 'Organophosphorus Chemistry', published by Royal Society of Chemistry, Cambridge, UK. Robert has worked alongside David on the Bedside Book of Chemistry and a major Thomson-Reuters report on the state of the pharmaceutical industry for the 2011 International Year of Chemistry