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Acid in the brain - University of Iowa researchers have developed an MRI-based method to detect and monitor pH changes in living brains. The new technique provides the best evidence so far that pH changes do occur with normal function in the intact human brain. The team hopes to use the method to investigate the role of pH changes in psychiatric disease, including anxiety and depression. The findings were published May 7 in the Proceedings of the National Academy of Sciences (PNAS) Early Edition.